BDBM199181 4-[(4-Carbamoylcyclohexyl)oxy]cyclohexane-1-carboxamide (OUL35)
SMILES NC(=O)c1ccc(Oc2ccc(cc2)C(N)=O)cc1
InChI Key InChIKey=XZRCQWLPMXFGHE-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 11 hits for monomerid = 199181
TargetProtein mono-ADP-ribosyltransferase PARP10(Homo sapiens (Human))
Mcdaniel College
Curated by ChEMBL
Mcdaniel College
Curated by ChEMBL
Affinity DataIC50: 646nMAssay Description:Inhibition of full length recombinant His6-tagged human PARP10 expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinyla...More data for this Ligand-Target Pair
TargetProtein mono-ADP-ribosyltransferase PARP10(Homo sapiens (Human))
Mcdaniel College
Curated by ChEMBL
Mcdaniel College
Curated by ChEMBL
Affinity DataIC50: 329nMAssay Description:Inhibition of full length recombinant His6-tagged PARP10 catalytic domain (unknown origin) expressed in Escherichia coli BL21(DE3) by fluorescence ba...More data for this Ligand-Target Pair
TargetProtein mono-ADP-ribosyltransferase PARP10(Homo sapiens (Human))
Mcdaniel College
Curated by ChEMBL
Mcdaniel College
Curated by ChEMBL
Affinity DataIC50: 640nMAssay Description:Inhibition of full length recombinant His6-tagged human PARP10 expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinyla...More data for this Ligand-Target Pair
TargetProtein mono-ADP-ribosyltransferase PARP10(Homo sapiens (Human))
Mcdaniel College
Curated by ChEMBL
Mcdaniel College
Curated by ChEMBL
Affinity DataIC50: 600nMAssay Description:Inhibition of C-terminal His-tagged human ARTD10 (809 to 1017 residues) R931A mutant expressed in Escherichia coli Rosetta2 (DE3) Rosetta2 (DE3) usin...More data for this Ligand-Target Pair
TargetProtein mono-ADP-ribosyltransferase PARP10(Homo sapiens (Human))
Mcdaniel College
Curated by ChEMBL
Mcdaniel College
Curated by ChEMBL
Affinity DataIC50: 330nMAssay Description:Inhibition of C-terminal His-tagged human ARTD10 (809 to 1017 residues) expressed in Escherichia coli Rosetta2 (DE3) using SRPK2 as substrate after 1...More data for this Ligand-Target Pair
TargetProtein mono-ADP-ribosyltransferase PARP10(Homo sapiens (Human))
Mcdaniel College
Curated by ChEMBL
Mcdaniel College
Curated by ChEMBL
Affinity DataIC50: 1.35E+3nMAssay Description:Inhibition of ARTD10 (unknown origin)-induced cell death expressed in human HeLa cells after 10 days by methylene blue staining based colony formatio...More data for this Ligand-Target Pair
TargetProtein mono-ADP-ribosyltransferase PARP10(Homo sapiens (Human))
Mcdaniel College
Curated by ChEMBL
Mcdaniel College
Curated by ChEMBL
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of human PARP10 catalytic domain assessed as reduction in MARylation of His6-tagged SRPK2 substrate after 60 mins in presence of NAD+ by c...More data for this Ligand-Target Pair
TargetProtein mono-ADP-ribosyltransferase PARP10(Homo sapiens (Human))
Mcdaniel College
Curated by ChEMBL
Mcdaniel College
Curated by ChEMBL
Affinity DataIC50: 1.32E+3nMAssay Description:Inhibition of human PARP10 catalytic domain assessed as reduction in MARylation of His6-tagged SRPK2 substrate after 60 mins in presence of NAD+ by c...More data for this Ligand-Target Pair
TargetProtein mono-ADP-ribosyltransferase PARP10(Homo sapiens (Human))
Mcdaniel College
Curated by ChEMBL
Mcdaniel College
Curated by ChEMBL
Affinity DataIC50: 330nMAssay Description:Inhibition of human 6His-tagged PARP10 (809 to 1017 residues) expressed in Escherichia coli Rosetta2 (DE3) cells by fluorescent based analysisMore data for this Ligand-Target Pair
TargetProtein mono-ADP-ribosyltransferase PARP10(Homo sapiens (Human))
Mcdaniel College
Curated by ChEMBL
Mcdaniel College
Curated by ChEMBL
Affinity DataIC50: 1.35E+3nMAssay Description:Inhibition of PARP10 in human HeLa cells assessed as increase in cell colonies incubated for 10 days with replacement with fresh medium for every 4 d...More data for this Ligand-Target Pair
TargetProtein mono-ADP-ribosyltransferase PARP10(Homo sapiens (Human))
Mcdaniel College
Curated by ChEMBL
Mcdaniel College
Curated by ChEMBL
Affinity DataIC50: 330nMAssay Description:Inhibition of PARP10 (unknown origin) expressed in Escherichia coli Rosette2 (DE3)More data for this Ligand-Target Pair